Bioreactor
Technology – Conventional
bioreactors that rely on impellers must balance mixing
considerations vs. biological shear sensitivity to
arrive at a compromise that often limits culture productivity. Resodyn
Corporation is developing bioreactors that employ ResonantAcoustics® agitation
which provides dramatically increased levels of mixing
at reduced shear stress levels, allowing greatly improved
culture productivity
Bioreactor Technology
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High-density
bioreactors require substantial amounts
of mixing in order to support the metabolic
needs of growing cells, but often require
low levels of hydrodynamic shear stress
that may damage cells. Conventional
bioreactors that rely on impellers to
drive bulk mixing and oxygen transport
must balance mixing vs. shear often leading
to limitations in culture productivity. Resodyn's
bioreactors replace impeller mixing units
with ResonantAcoustics® agitation
which greatly enhances oxygen transfer
and micromixing while imparting very
low levels of hydrodynamic shear stress. In
addition, the benefits of ResonantAcoustics® agitation
become more pronounced as culture viscosity
increases. Not only can culture
productivity for traditional applications
be dramatically improved, but many of
the design constraints of traditional
bioreactors (specific geometries, air
flow rates, etc.) can be relaxed, resulting
in optimal solutions for unique cell
culture and tissue engineering challenges. |
Features:
• ResonantAcoustics® bioreactors
enable very high levels of oxygen transfer (high values)
• High viscosity cell broths are very efficiently mixed using ResonantAcoustics® bioreactors
Benefits:
• High cell densities achievable
• Low shear stress and cell damage
• Novel bioreactor designs enabled
Applications:
• Pharmaceutical production from mammalian cell culture
• Enzyme and metabolite production from fungal cell culture
• Bacterial, yeast, and plant cell cultures
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