Tissue Engineering – Both cell growth on biodegradable scaffolds and various tissue processing steps require high levels of mass transfer with low shear stress to produce optimal results. Resodyn is developing new processes and devices for the tissue engineering industry that utilize the ResonantAcoustics® agitation system for a wide range of tissue engineering applications.

The field of tissue engineering combines biological, materials, and engineering expertise to create medical products that replace and enhance failing human tissues. Such tissues include skin, bone, cartilage, blood vessels, liver, bone marrow and many others. In order to produce tissue replacements outside the body (ex vivo), a biodegradable scaffold is often seeded with the appropriate cell type for growth into the desired tissue. Proper growth requires the transfer of sufficient amounts of nutrients and oxygen to the tissues in order to support their growth. Given the various shapes and sizes of different tissue constructs, conventional bioreactor devices with impeller mixers are often not effective for providing mixing and mass transfer. In addition, during the production of different types of tissue products, processing steps which need efficient mass transfer are highly prevalent. Such steps include chemical sterilization, enzymatic digestion, and rehydration. Resodyn is developing new processes and devices for the tissue engineering industry that utilize the ResonantAcoustics® agitation system for a wide range of applications.

    Features:
•  Increased mass transfer into biodegradable scaffolds
•  Low hydrodynamic shear stress

    Benefits:
•  Improved growth rates of tissue engineered constructs
•  Reduced times for multiple tissue processing procedures

    Applications:
•  Growth of human tissue on biodegradable scaffolds
•  Processing of human tissue for medical applications

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